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J Intern Med 290(2):257278 Demase K, Monitto CK, Little RD, Sparrow MP (2023) The role of low-dose oral methotrexate in increasing anti-TNF drug levels and reducing immunogenicity in IBD

This reduction suppresses LONP1 expression and activity, leading to mitochondrial dysfunction and elevated oxidative stress [34]

However, the absence of a direct drug-drug interaction does not mean these medications can be combined without consideration

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Jiang, B

Furthermore, the generalizability of our results to certain high-risk populations, such as individuals with advanced CKD or those with HF with reduced EF, remains uncertain due to underrepresentation of these subgroups in the included trials