This variability is influenced by differences in the permeability of the bloodbrain barrier (BBB) and the bloodcerebrospinal fluid (CSF) barrier, as well as by region-specific expression of enzymes involved in glutathione metabolism
Diet, gut microbiota and immune responses
Disclaimer: The information presented here is provided for scientific and educational purposes only
49th American College of Neuropsychopharmacology Annual Meeting, Miami, Fl., December 5
In conclusion, while clinical translation is constrained by delivery, toxicity, and pharmacokinetic hurdles, ferritin-targeted approaches offer a novel and mechanistically rational avenue for treating aggressive brain cancers, warranting further preclinical optimization and early-phase clinical investigation
K.ChenD.WruckC