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Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects

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Secretagogues like these two work by amplifying that pulsatile pattern rather than overriding it which is also why, in research settings, GH secretagogues have typically been administered to coincide with the natural nocturnal pulse

TRIUMPH-1 confirmed it at 12.5% in a general obesity population, lower than TRIUMPH-4's 20.9% but still substantial