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However, inhibition of SIRT6 and AMPK , which were increased by GLP-1RAs, reversed the suppression of SREBP-2 and its downstream factor genes and amplified the increase in expression of the LDLR gene in PA-treated HepG2 cells
These medications work by mimicking the GLP1 hormone, which helps regulate blood sugar levels, slow gastric emptying, and promote feelings of fullness
On the other hand, retatrutide is a triple GLP-1 receptors agonist that mimics the effects of GLP-1, GIP, and glucagon
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