cagrilintide semaglutide cagrisema phase 3 results 2024 2025 combination RESEARCH ARTICLE: Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1 @SubodhVermaMD https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.125.26055 Novo's CagriSema loses phase 3

The scientific limitations of transdermal delivery for large molecules make their marketing claims implausible, and no clinical evidence supports their effectiveness for weight loss

Is it the real deal, or just another weight-loss trend

Fat cells are a prime factor in gaining or losing weight

Surprisingly, the SURMOUNT-5 trial found that fewer people discontinued tirzepatide due to side effects (2.7%) compared to semaglutide (5.6%)

A legitimate pharmacy can still have shipping problems

Someone can wear a smaller size, weigh less than they have in years, and still have less muscle and a higher fat percentage than when they started