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102 Compared with the structure of human GLP-1(7-36), the amino acid sequence of albiglutide contains an arginine at position 8 (in GLP-1, this residue is lysine), and two modified GLP-1 peptide chains are fused to human serum albumin (HSA), thereby greatly extending its half-life
Much of this has been due to further clinical results that showed stronger weight loss efficacy for Zepbound
It is important to note that retatrutide has not yet received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for clinical use in the UK
In the Phase 3 TRIUMPH-1 trial , adults with overweight or obesity who took just 4 mg of retatrutide for 80 weeks lost 19% of their starting body weight
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