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Elevated IGF-1 feeds back to suppress further GHRH release, which limits how far the axis can be driven

Melanie Avalon Yeah, it's interesting

[email protected] This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

He P, Xiong Y, Ye J, Chen B, Cheng H, Liu H, Zheng Y, Chu C, Mao J, Chen A, Zhang Y, Li J, Tian J, Liu G

This makes it a practical adjunct for researchers running 12-week or extended protocols who want to protect receptor function without shortening the cycle itself

These results may be owing to MTX induced-oxidative stress, which leads to oxidant/anti-oxidant imbalance