Common side effects , particularly during the initial weeks of treatment, include: Nausea (reported in up to 20% of patients) Diarrhoea or constipation Decreased appetite Abdominal discomfort or bloating Fatigue or mild headache These gastrointestinal symptoms are usually mild to moderate and tend to diminish as the body adjusts to the medication, typically within 24 weeks
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For these reasons, employers are increasingly weaving GLP-1 coverage into existing wellness programs, disease management platforms, and mental health resources
10.1038/sigtrans.2017.23 63 LiuS.JinX.GeY.DongJ.LiuX.PeiX.et al (2025)
Because the delivery method fails them, not the molecule
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