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Abnormal patterns of N-glycosylation and O-GlcNAcylation are commonly found in tumor cells and can also affect the functions of immune cells [175]

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However, additional investigation is necessary to clarify the regulatory mechanisms that connect these two processes

The hyperglycemia-related increased proximal tubular sodium reabsorption results in lower sodium levels at the level of the macula densa increasing GFR via inhibiting TGF, further augmenting the amount of filtered and reabsorbed sodium with increased ATP demands