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This extended gastric retention leads to prolonged satiety after meals and a more gradual release of nutrients into the bloodstream, helping reduce sharp post-meal glucose fluctuations
The remarkable diversity of these mechanisms reflects both the complex, redundant nature of inflammatory pathways in UC and the recognition that single-target approaches may have inherent efficacy limitations, potentially necessitating either highly selective patient stratification based on dominant pathogenic mechanisms or rational combination strategies targeting complementary pathways
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In addition to taking either semaglutide or placebo for the trial, all participants also received standard-of-care treatment for cardiovascular disease, such as cholesterol-modifying medications, antiplatelet therapies, beta blockers or other treatments
