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A phase II trial focusing on individuals with overweight or obesity, coupled with hypertension or dyslipidemia but without T2D, found that cagrilintide (2.4 mg) alongside diet and exercise, led to a 10% body weight reduction compared to 3% with placebo over 26 weeks [99]

Integrating Lifestyle Changes for Maximum Benefit The effectiveness of GLP-1 drugs is amplified when combined with comprehensive lifestyle modifications

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In the same Redox Biology study, GLP-1treated patients exhibited increased leukocyte rolling velocity and reduced adhesion compared with untreated individuals [15]

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Strong initial sales of the Wegovy pill will set the tone for the success of the drug in 2026 and beyond, especially in light of an anticipated orforglipron approval in April