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The anti-inflammatory effect of curcumin is most likely associated with its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS) (164)
490 Excessive inhibition of Nrf2 may not improve DOX-induced cardiomyopathy due to insufficient promotion of antioxidant gene expression, while its overactivation increases the breakdown of heme and ferrous iron levels in the HO-1-catalyzed manner, promoting ferroptosis
however, two patients in the FWGE group had metastatic disease at the beginning of the study, while their paired counterparts did not
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