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Despite the favorable CYP profiles for some of the compounds, all five molecules triggered at least one PAINS alert that was most associated with catechol_A substructures
Journal of Endocrinology, 236(2), 63-78
Reunanen, J
In whole-cell current clamp experiments, hyperpolarizing or depolarizing current pulses (500 ms, from 10 to 30 pA in 5-pA steps) were injected into neurons to determine input resistances or trigger action potentials
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