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10.1007/s11103-009-9458-1 17 BollerT.HeS

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Superoxide dismutase protects against oxidative damage

Patients on metformin and another antihyperglycemic agent (N=229) and patients not on any antihyperglycemic agents (off therapy for at least 8 weeks, N=41) were randomized after a run-in period of approximately 10 weeks on metformin HCl (at a dose of at least 1500 mg per day) in monotherapy