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The results showed that activation of the GSK3-Drp1 cascade is dysregulated in the RV of rats subjected to PAB surgery, as evidenced by decreased phosphorylation of GSK3 at Ser9 (GSK3 S9), elevated phosphorylation of Drp1 at Ser616 (Drp1 S616), and decreased phosphorylation of Drp1 at Ser637 (Drp1 S637) (Fig

Side effects are typically most noticeable during the first few weeks

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This pathway can phosphorylate pro-apoptotic proteins such as Bax and Bak, which belong to the Bcl-2 family

FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation

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