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A natural dual GLP-1/glucagon agonist exists in the shape of oxyntomodulin, a 37 amino acid peptide which is co-secreted with GLP-1 from the l-cells of the small intestine as an additional product of the differential processing of proglucagon in the gut (see Fig

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Unlike previous treatment models that focused solely on inflammatory responses, this approach not only effectively suppresses immune overreactions but also creates a favorable immune environment for tissue repair, offering a new translational medicine approach for IRI treatment that transitions from symptom control to mechanism intervention

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