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Plant, Cell Environ
Succinylation of PKM2 promotes its transition from a tetramer to a dimer and its entry into the nucleus, subsequently activating the NLRP3/AIM2 inflammasome and exacerbating macrophage pyroptosis and the release of inflammatory factors (IL-1, HMGB1) ( 5.3 From monitoring to remodeling: translational medicine prospects of macrophage exosomes Given the high plasticity of macrophages during the initiation and resolution phases of ARDS inflammation, transforming their exosomes from simple pathological products into clinical diagnostic and therapeutic tools represents a significant breakthrough direction in the field of critical care immunology
References are informational
Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, Terasaki T
Dietary Sources of Selenium Organ meats, muscle meats, and seafood have the highest selenium content
Physical activity plays a critical role, especially in preserving muscle mass
