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Clinical Recognition and Therapeutic Development (1980Present) The shift from biochemical curiosity to clinical intervention accelerated in the 1980s when Dean Jones at Emory University demonstrated that glutathione status could be manipulated therapeutically using N-acetylcysteine (NAC), a precursor that bypasses the rate-limiting step in glutathione synthesis

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2007;87(4):1409-1439 2 Mller TD, Finan B, Clemmensen C, DiMarchi RD, Tschp MH

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