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The tirzepatide drugs, such as Mounjaro and Zepbound, target the GLP-1 pathway along with a second one, the GIP pathway
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PMID: 10803423
This cleavage generates the membrane-bound C-terminal fragment CTF99, which is subsequently processed by -secretase to release A peptides of 4042 amino acids (Neha and Parvez, 2023)
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