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Due to neurons having a limited capacity for GSH synthesis, they must rely on astrocytes to supply precursors such as cysteine (Prez-Sala D and Pajares, 2023)

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doi: 10.1016/j.nut.2016.12.018 33 CarcaterraM.CarusoC

Metabolomics analysis and data processing Metabolite extraction was performed by adding a cold solvent mixture of acetonitrile: isopropanol: water (3:3:2, v/v/v) to a homogenized tissue aliquot of 25 mg sea urchin gonad followed by centrifugation and drying of the supernatant as per Fiehn 37

Several sources of ROS have been identified during diabetes, including enhanced blood glucose flux through the polyol and hexosamine pathway, increased formation of advanced glycation end products, and activation of protein kinase C pathway (137, 138)