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These data indicate that the weight loss effects of the mGIPR-Ab/GLP-1 peptideantibody conjugate are not exclusively driven by GLP-1R agonism

For adults with binge-eating disorder, the most common side effects are dry mouth, insomnia, decreased appetite, and increased heart rate

The parent compound may be undetectable within hours

GLP-1 did not increase myocardial oxygen consumption or blood flow in humans or in swine, increasing p38-MAPK activity in lean, but not obese cardiac tissue [48]