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GLP-1 also increases pancreatic -cell proliferation by stimulating genes involved in cell proliferation and decreases the apoptosis of these cells by inhibiting caspase-3 expression
For instance, GLP-1RA have been tested in people with serious mental illness, who could be at a high suicidality risk, showing metabolic benefits with no increase in psychopathology or occurrence of SIS [22]
For patients with diabetic retinopathy, semaglutide requires additional caution due to potential worsening during rapid glucose improvement
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