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In Overt B12 deficiency, serum vitamin B12 is generally below 200 pmol/L (274 ug/L), and is the result of insufficient intake of vitamin B12 by the mother, due to a vegan or vegetarian diet

After the loading phase, most patients move to monthly maintenance, sometimes adjusted to every three to six weeks depending on lifestyle demands, travel and skin goals

For gut healing and systemic wellness, oral capsules of 500mcg taken once or twice daily are common

They're available as injections and can be prescribed through telehealth when clinically appropriate

& Wyatt, R

Every peptide bond is theoretically susceptible to hydrolysis, but some are more vulnerable than others