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As recently reviewed (Zanetti and Puoti, 2013), the germline sex determination is executed through an elaborate pathway involving more than 30 regulators for sperm or oocyte specification, part of which is shown in Figure 2C

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Since elevated Akt activity in the early postprandial stage is required to reduce HGP and Akt activity in the late stage is sufficient to increase de novo lipogenesis but not HGP [40,43,44], unterminated prolonged Akt activity might enhance de novo lipogenesis but not suppress HGP