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Thyroid cancer : Possible risk of thyroid tumors based on rodent studies

Reported effects below derive from the published preclinical and in vitro literature on the individual components not from human clinical trials of the KLOW blend specifically

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For the subsequent pathway that convert BB to TMA encoded by the gbu gene cluster, the abundance of gbu genes, including gbuABCDEF , was all significantly increased in the HP group as compared with the LP groups ( cntAB genes and cai operon showed insignificant difference between HP and LP, whereas the abundance of gbuABCDEF was consistently increased in HP when compared with LP in the HC2 and CV cohorts ( TMAO production via the microbial gbu pathway can be modulated by L-carnitine supplementation and plant-based diet intervention To further understand whether the microbial gbu gene cluster in the gut microbiota could be altered by dietary intervention, we analyzed the L-carnitine-specific TMAO-producing capacity and the abundance of gbu genes under dietary interventions in the HC1 and CV cohorts

Catalano PM, Shankar K