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[PubMed]32
Hydrogen exerts anti-inflammatory effect by suppressing the expression of factors involved in promoting inflammation, such as NF-B, TNF-, IL-6, CCL2, and INF- 40,41
The result, after nearly two decades of development, was exenatide (Byetta) , which received FDA approval in April 2005 as the first GLP-1 receptor agonist approved for clinical use
The PI3K/AKT pathway, frequently hyperactivated in cancers due to mutations like those in PIK3CA, drives metabolic reprogramming and enhances antioxidant defenses by stimulating GSH biosynthesis [49]
Metabolism: clinical and experimental , 46 (1), 8996
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