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The current studies suggest a reduced ability to clear out misfolded, oligomerized and aggregated tau proteins that increase with advancing age (36, 37)

Moreover, conditioned media from activated fibroblasts and exogenous lactate have been shown to trigger the expression of profibrotic genes in macrophages by inducing histone lactylation [17]

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Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study