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In particular, the physiological role of LEAP2 beyond GHSR antagonism, the tissue-specific actions of ghrelin and desacyl-ghrelin, and the functional relevance of the ghrelin/LEAP2 ratio across different metabolic states require further clarification

Schultz M.D

Both pathways converge on vesicular GH release but operate independently at the receptor and second-messenger level researchers studying combined protocols can compare GH pulse profiles under single-class versus dual-class stimulation

When discontinued, weight regain is common a key challenge for long-term maintenance