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In CIPN in vivo models induced by cisplatin, postmitotic sensory neurons in the dorsal root ganglion (DRG) are particularly sensitive to cisplatin injury, and axonal damage induced by cisplatin involves multiple events, including ROS generation, suggesting that antioxidants may help reduce the neurotoxicity of cisplatin [124, 125]

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Although it was registered in a clinical trial under the name Bepecin in 2015, the study did not result in any approved uses for this substance

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PMID: 25685110

This leads to an imbalance that may reduce GLP-1 secretion