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While the threshold of UA levels that demonstrate significant anti-oxidant and anti-inflammatory properties remains unknown, studies have shown that within the physiological range in human blood, UA exhibits a dose-dependent anti-inflammatory effect [53]

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MT reduces oxidative damage by upregulating nuclear factor erythroid 2 2-related factor 2 (Nrf2) through the SIRT1/Nrf2 axis, which promotes the transcription of antioxidant enzymes through antioxidant response elements (AREs) (Yang et al

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