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The practical result is that tirzepatide tends to produce stronger appetite suppression, greater fat loss relative to lean mass, and improved metabolic markers compared to semaglutide at their respective optimal doses
Never take multiple doses at one time
Additional regulations None Nebraska Who can prescribe semaglutide
In STEP-1, participants taking semaglutide 2.4mg weekly lost an average of 14.9% of body weight over 68 weeks
Results from Eli Lilly's Phase 2 trial (Jastreboff et al., New England Journal of Medicine, 2023) reported mean body weight reductions of approximately 1724% over 48 weeks depending on dose, which has generated considerable scientific interest
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