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Previous studies in mice have reported that matched, unbiased agonists are less effective at controlling glucose and body weight than GLP-1RAs with bias similar to that of tirzepatide [35, 36]

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Randomised withdrawal trials including STEP 4 and SURMOUNT-4 show that discontinuation is consistently followed by rapid regain, and a 2026 review in EClinicalMedicine reports that roughly two-thirds of lost weight is typically regained within a year of stopping

Medication Options and Costs Providers typically start patients off with a lower dose of GLP-1s to minimize side effects, and this titration is reflected in the pricing

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GLP-1 drugs (also called GLP-1 agonists) are medications originally marketed to treat diabetes