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Moreover, metformin has been demonstrated to independently regulate menstrual cycles and ovulation, which further enhances fertility ( 2 Mechanisms of metformin alleviating anovulatory infertility in polycystic ovary syndrome For females of childbearing age, the most significant consequence of PCOS is infertility, for which the pathogenesis is still unclear

For those on semaglutide, discussing these symptoms with a healthcare provider is essential, as adjustments to treatment or additional diagnostic testing may be necessary

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Additionally, disturbances in autophagy-lysosome degradation process, where the assembly of ATPases was interrupted and the lysosome in RPE cells was alkalinized, led to the digestion of ACSL4 protein, and ultimately to ferroptosis (91)