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Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function
This began due to GLP-1 shortages and has gained traction, prompting people to explore whether they can still see benefits
doi: 10.1016/S0140-6736(78)92994-X 6 DiakogiannakiEGribbleFMReimannF
It is derived from a protein found naturally in human gastric juice
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