This indicates that a substantial portion of EC and its conjugates reaches the colon unabsorbed, where microbial enzymes cleave glycosidic linkages and initiate catabolic conversion into ring-opened and chain-shortened phenolic acids
The GLP-1RAs are achieving blockbuster status, meaning a drug that generates yearly sales exceeding one billion dollars for a drug company
The 2025 meta-analysis by Alfalasi and colleagues, published via PMC, synthesized data from 16 studies and 6,098 total participants
Research has found that these medicines can reduce the risk of cardiovascular disease
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However, they state further research should be explored to include a more diverse cohort of participants, given those from the US Department of Veterans Affairs are mostly older, white males