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Chronic exposure to high glucose in intestinal organoids impairs the expression of transcription factors related to the differentiation of early and late endocrine progenitors and L-cell development including Ngn3 and Neurod1
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Other reported risk factors include atrial fibrillation, hyperthyroidism, vitamin D and folic acid deficiency, hyperuricemia, depression and anxiety disorders, chronic kidney and rheumatic disease, COPD, migraine, inflammatory bowel disease, osteoporosis, and sleep disorders [266,272-285]
Foot care in diabetes: the human and financial cost
