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To thwart this, nanomedicines have been discovered that include ROS generation and GSH depletion [75]

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The debilitating, slow damage created by high levels of blood sugar (glucose) destroys everything from your blood vessels to your eyes, kidneys, and nerves over time due to oxidative stress (remember the free radicals or reactive oxygen species (ROS)?)

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10.1542/peds.2012-0900E 63