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This does not mean weight regain is inevitable or total, but it does reflect an important biological reality: GLP-1 medications work in part by suppressing appetite and slowing gastric emptying, and when the medication stops, those effects stop too
The combination of excellent glucose control, substantial weight loss, cardiovascular protection, and kidney benefits makes these medications the clear first choice for many patients
Both medications are very effective at controlling blood sugar levels and aiding in weight loss, with retatrutide showing a small advantage in trials, but semaglutide has more long-term data as its already been FDA-approved
The patients who received the GLP-1 infusion had a significant improvement in left ventricular ejection fraction, VO2 max, and 6-minute walking distance