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Limitations of Current Evidence The absence of large-scale human clinical trials represents the primary evidence gap

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These options are commonly used for mild to moderate acne, or for those who prefer to avoid Accutane due to its side effect profile or monitoring requirements

In reality, some whitening creams may, in certain cases, contain undisclosed topical steroids or other potent ingredients that can produce rapid lightening effects but may also increase the risk of skin thinning, irritation, sensitivity, breakouts, and other long-term skin concerns

Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request

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