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Upon reperfusion, this accumulated succinate is rapidly oxidized by succinate dehydrogenase (SDH, Complex II), leading to a highly reduced coenzyme Q (CoQ) pool

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Genomics 1993

The glucagonostatic characteristics of GLP-1 RA could prove to be more relevant to individuals with beta cell deficiency [51] which contrasts with type 2 diabetes where beta cell dysfunction and impaired incretin effect may dominate [52]