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They are sometimes discussed in research or aesthetic contexts, but their real-world use carries known risks and unknown long-term effects

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However, rebound effects are common: Appetite rebound: Many patients experience an increase of 200400 calories per day in appetite, typically peaking around week 2 after stopping

Patients on tirzepatide frequently experience gastrointestinal side effects, including nausea, constipation , and diarrhea

Drinking water alongside alcohol is more important than usual

However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy