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Cold solutions cause discomfort and may absorb differently than room temperature preparations
Setmelanotide, a selective MC4R agonist, received FDA approval in 2020 specifically for rare genetic obesity syndromes involving POMC or leptin receptor deficiency
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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]
If taken twice daily as an immediate-release product, that reaches 100 mg sitagliptin and 2000 mg metformin per day
Diarrhea: Reported at higher rates with increasing doses
