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Table 3 summarizes the pooled data on the gastrointestinal adverse reactions observed in the SURPASS-1 to SURPASS-5 studies for T2D therapy in comparison to placebo (61)
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However, because this excretion accounts for less than 1% of total acylcarnitine elimination in urine [43], it is unlikely that excretion of VPA alone is sufficient to produce carnitine deficiency in well nourished patients [44]
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