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Journal of Experimental Pharmacology, 2012

no Phase II or III trials published Most common AOD-9604 side effect / Injection-site reaction (redness, swelling) Most common reported MOTS-c side effect / Transient flushing and mild GI discomfort (anecdotal, not trial-confirmed) Growth hormone axis impact / AOD-9604 does not activate the GH receptor

Subgroup and Sensitivity Findings Analyses stratified by age, sex, SGLT2 inhibitor co-use, and cardiovascular risk revealed no significant heterogeneity, supporting the external validity of the findings across typical clinical populations

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Sources Ruder, K

These symptoms are usually temporary and improve as the body adjusts