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This ensures the B12 remains in the muscle for steady release rather than being dispersed too quickly

16 This mechanism has been further strengthened by in vivo evidence from murine bilateral renal ischemia-reperfusion injury models, in which vesicles released from injured tubules have been shown to carry the long non-coding RNA WAC-AS1 and suppress antioxidant defenses in neighboring tubular cells

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FPN is regulated by hepcidin, a hepatic-secreted peptide hormone, which promotes the internalization and degradation of FPN [74]

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