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Moderate-intensity physical activity upregulates proteins such as BECLIN1, microtubule-associated protein 1 light chain 3 (LC3), and autophagy-related protein 12 (ATG12), thereby enhancing autophagy, reducing ROS production, inhibiting NLRP3 inflammasome activation, and lowering IL-1 and IL-18 levels, ultimately restoring cellular homeostasis and reducing age-related inflammation [99]

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