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Further studies aimed at elucidating the exact mechanisms underlying RSL3-induced DNA damage are needed

Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice

Overall, irreparable damage to membranous organelles, spindle microtubules, cellular DNA, and the heat shock system itself leads to profound dysfunction of gametes and embryos and even apoptotic cell death, all of which adversely impact fertility (84, 85, 107, 109, 110, 152, 153)

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