Preclinical studies demonstrated that GLP-1 receptor agonists increased bone formation and reduced bone resorption in metabolic bone disease models, including diabetic osteoporosis, postmenopausal osteoporosis, and glucocorticoid-induced osteoporosis
Fiber adds bulk and draws water into stool, leading to more comfortable bowel movements
These dual incretin therapies are gaining physician acceptance as they deliver strong weight reduction and metabolic outcomes
6.2 Modulation of gut microbiota Recent research suggests that GLP-1 receptor agonists significantly affect the composition of gut microbiota, revealing a new mechanism that contributes to metabolic advantages (Liang et al
In addition, throughout stages of menopause there is a natural acceleration in both a reduction in lean muscle mass and a decline in estrogen production and release
Patients should report any side effects to their healthcare provider, who can advise on management strategies and adjust treatment if necessary