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Immunoreactive urocortin has been localized in the syncytiotrophoblast and fetal membranes, and it is 25 times more potent than CRH in causing vasodilation of the fetal placental vasculature in vitro.221 However, the importance of urocortin in modulating placental vascular resistance in vivo and in the fetal response to stress has not been elucidated

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