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Oz told reporters that CMS plans to carefully track participation and outcomes to see whether an extension of the Bridge program or another solution is the best way to move forward

For perspective on what these results look like in practice, real-world tirzepatide transformations confirm what the trials showed

Rarely, patients report sudden painless vision loss or other urgent symptoms that require immediate evaluation to rule out serious conditions

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Wegovy Injection: Initial dose (weeks 1 through 4): 0.25 mg subcutaneously once a week Dose escalation: Weeks 5 through 8: 0.5 mg subcutaneously once a week Weeks 9 through 12: 1 mg subcutaneously once a week Weeks 13 through 16: 1.7 mg subcutaneously once a week Alternatively: 1.7 mg subcutaneously once a week Comments: Major adverse cardiovascular (CV) events include CV death, nonfatal myocardial infarction, or nonfatal stroke

TRIUMPH-4 Results (December 2025): The First Phase 3 Data TRIUMPH-4 was the first Phase 3 trial to read out and the first concrete look at retatrutide's efficacy outside the Phase 2 cohort